Pharmacodynamic biomarkers of long-term interferon beta-1a therapy in REFLEX and REFLEXION.
J Neuroimmunol
; 360: 577715, 2021 11 15.
Article
em En
| MEDLINE
| ID: mdl-34536787
ABSTRACT
This post-hoc analysis evaluated candidate biomarkers of long-term efficacy of subcutaneous interferon beta-1a (sc IFN ß-1a) in REFLEX/REFLEXION studies of clinically isolated syndrome. Samples from 507 REFLEX and 287 REFLEXION study participants were analyzed. All investigated biomarkers were significantly upregulated 1.5-4-fold in response to sc IFN ß-1a treatment versus baseline (p ≤ 0.008). The validity of MX1, 2'5'OAS, and IL-1RA as biomarkers of response to sc IFN ß-1a was confirmed in this large patient cohort, with biomarkers consistently upregulated in a dose-dependent manner. Neopterin, TRAIL, and IP-10 were confirmed as biomarkers associated with long-term sc IFN ß-1a treatment efficacy over 5 years.
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Base de dados:
MEDLINE
Assunto principal:
Interferon beta-1a
/
Esclerose Múltipla
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article