Quantification of cognitive impairment to characterize heterogeneity of patients at risk of developing Alzheimer's disease dementia.
Alzheimers Dement (Amst)
; 13(1): e12237, 2021.
Article
em En
| MEDLINE
| ID: mdl-34541290
ABSTRACT
INTRODUCTION:
Neuropsychological test scores are limited and standard outcomes may mask the heterogeneity of cognitive impairment. This article presents the calculation and evaluation of six composite scores that quantify domain-specific impairment.METHODS:
Parameters for composite scores calculation were learned by performing confirmatory factor analysis in a sample of participants from the Alzheimer's Disease Neuroimaging Initiative database. The obtained scores were evaluated with a separate sample of mild cognitive impairment (MCI) in two automated tasks unsupervised partition in different subgroups and prediction of progression to dementia for different time windows.RESULTS:
MCI subgroups with distinctive cognitive profiles and risk of progression emerged from cluster analysis. Composite scores outperform standard neuropsychological tests when automatically predicting progression within time windows up to 5 years.CONCLUSIONS:
Domain-specific composite scores are useful to delineate profiles of impairment, stratify the MCI risk, and predict progression to dementia.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article