Lipid specificity of the immune effector perforin.
Faraday Discuss
; 232(0): 236-255, 2021 12 24.
Article
em En
| MEDLINE
| ID: mdl-34545865
ABSTRACT
Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune response. During the response, the lymphocyte membrane becomes refractory to perforin function by accumulating densely ordered lipid rafts and externalizing negatively charged lipid species. The dense membrane packing lowers the capacity of perforin to bind, and the negatively charged lipids scavenge any residual protein before pore formation. Using atomic force microscopy on model membrane systems, we here provide insight into the molecular basis of perforin lipid specificity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
/
Lipídeos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article