Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis.
Medicine (Baltimore)
; 100(38): e27151, 2021 Sep 24.
Article
em En
| MEDLINE
| ID: mdl-34559104
ABSTRACT
PURPOSE:
This study aimed to assess the efficacy of traditional Chinese medicine (TCM) in septic patients treated with ulinastatin.METHODS:
PubMed, EmBase, and the Cochrane library were searched up to January 2021 to identify randomized controlled trials. The weight mean difference (WMD) and relative risk (RR) with 95% confidence intervals were used with the random-effects model.RESULTS:
Twenty-three randomized controlled trials with 1903 septic patients were included. TCM significantly reduced the APACHE II score (WMD -5.18; Pâ<â.001), interleukin-6 (WMD -63.00; Pâ<â.001), tumor necrosis factor-α (WMD -8.86; Pâ<â.001), c-reactive protein (WMD -9.47; Pâ<â.001), mechanical ventilation duration (WMD -3.98; Pâ<â.001), intensive care unit stay (WMD -4.18; Pâ<â.001), procalcitonin (WMD -0.53; Pâ<â.001), lipopolysaccharide (WMD -9.69; Pâ<â.001), B-type natriuretic peptide (WMD -159.87; Pâ<â.001), creatine kinase isoenzyme MB (WMD -45.67; Pâ<â.001), cardiac troponin I (WMD -0.66; Pâ<â.001), and all-cause mortality risk (RR 0.55; Pâ<â.001).CONCLUSIONS:
TCM lowers inflammation levels and reduces the risk of all-cause mortality for septic patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Glicoproteínas
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Inibidores da Tripsina
/
Sepse
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article