Polycyclodextrin as a linker for nanomedicine fabrication and synergistic anticancer application.
Carbohydr Polym
; 273: 118608, 2021 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-34561007
ABSTRACT
Polycyclodextrin (denoted PCD) composed of cyclodextrin monomer units and 1,3-diethoxypropan-2-ol containing many hydroxyl groups with lone pairs of electrons, easily coordinated with transition metals with empty orbitals. The CD unit can also provide host-guest binding sites for functional molecules. This article utilizes this feature of PCD for the first time as a "linker" to combine transition metal nanomaterials with synergistic functional molecules. We synthesized PCD with 50% CD monomer by epichlorohydrin cross-linking method. Utilizing the coordination effect of the hydroxyl group in PCD and the iron ion in photothermal nanoparticles (PB-Yb), the PCD is coated on its surface; simultaneously, CD in PCD can form a host-guest complex with adamantane-modified zinc phthalocyanine (Pc) photosensitizer. Using PCD as a "linker", PB-Yb and Pc (denoted PYPP) were combined to improve the solubility of PB-Yb, reduce the aggregation degree of Pc to increase their activity, and achieve photothermal and photodynamic synergistic tumor therapy.
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Base de dados:
MEDLINE
Assunto principal:
Polímeros
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Fármacos Fotossensibilizantes
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Ciclodextrinas
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Nanopartículas
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Neoplasias
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Antineoplásicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article