A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.

Park, Hae-Eun H; Hwang, Wooseon; Ham, Seokjin; Kim, Eunah; Altintas, Ozlem; Park, Sangsoon; Son, Heehwa G; Lee, Yujin; Lee, Dongyeop; Heo, Won Do; Lee, Seung-Jae V

Park, Hae-Eun H; Hwang, Wooseon; Ham, Seokjin; Kim, Eunah; Altintas, Ozlem; Park, Sangsoon; Son, Heehwa G; Lee, Yujin; Lee, Dongyeop; Heo, Won Do; Lee, Seung-Jae V.

Afiliação

Park HH; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Hwang W; Department of Life Sciences, Pohang University of Science and Technology, Pohang, 37673, South Korea.
Ham S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Kim E; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Altintas O; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, 37673, South Korea.
Park S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Son HG; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Lee Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Lee D; Department of Life Sciences, Pohang University of Science and Technology, Pohang, 37673, South Korea.
Heo WD; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Lee SV; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea. seungjaevlee@kaist.ac.kr.

Nat Commun ; 12(1): 5631, 2021 09 24.

Article em En | MEDLINE | ID: mdl-34561453

Assuntos

Proteínas de Caenorhabditis elegans/genética; Caenorhabditis elegans/genética; Longevidade/genética; Mutação; PTEN Fosfo-Hidrolase/genética; Receptor IGF Tipo 1/genética; Animais; Animais Geneticamente Modificados; Caenorhabditis elegans/metabolismo; Proteínas de Caenorhabditis elegans/metabolismo; Fatores de Transcrição Forkhead/genética; Fatores de Transcrição Forkhead/metabolismo; Aptidão Genética/genética; Proteínas de Fluorescência Verde/genética; Proteínas de Fluorescência Verde/metabolismo; Microscopia de Fluorescência/métodos; PTEN Fosfo-Hidrolase/metabolismo; RNA-Seq/métodos; Receptor IGF Tipo 1/metabolismo; Receptor de Insulina/genética; Receptor de Insulina/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor IGF Tipo 1 / Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / PTEN Fosfo-Hidrolase / Longevidade / Mutação Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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