X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study.
Sci Rep
; 11(1): 19021, 2021 09 24.
Article
em En
| MEDLINE
| ID: mdl-34561476
ABSTRACT
Gout is the most common form of inflammatory arthritis, caused by the deposition of monosodium urate (MSU) crystals in peripheral joints and tissue. Detection of MSU crystals is essential for definitive diagnosis, however the gold standard is an invasive process which is rarely utilized. In fact, most patients are diagnosed or even misdiagnosed based on manifested clinical signs, as indicated by the unchanged premature mortality among gout patients over the past decade, although effective treatment is now available. An alternative, non-invasive approach for the detection of MSU crystals is X-ray dark-field radiography. In our work, we demonstrate that dark-field X-ray radiography can detect naturally developed gout in animals with high diagnostic sensitivity and specificity based on the in situ measurement of MSU crystals. With the results of this study as a potential basis for further research, we believe that X-ray dark-field radiography has the potential to substantially improve gout diagnostics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Úrico
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Radiografia
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Gota
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Articulações
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article