Endogenous microRNA triggered enzyme-free DNA logic self-assembly for amplified bioimaging and enhanced gene therapy via in situ generation of siRNAs.

Jiang, Qinghua; Yue, Shuzhen; Yu, Kaixin; Tian, Tian; Zhang, Jian; Chu, Huijun; Cui, Zhumei; Bi, Sai

Jiang, Qinghua; Yue, Shuzhen; Yu, Kaixin; Tian, Tian; Zhang, Jian; Chu, Huijun; Cui, Zhumei; Bi, Sai.

Afiliação

Jiang Q; Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, People's Republic of China.
Yue S; College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071, People's Republic of China.
Yu K; College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071, People's Republic of China.
Tian T; Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, People's Republic of China.
Zhang J; College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071, People's Republic of China.
Chu H; Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, People's Republic of China.
Cui Z; Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, People's Republic of China. cuizhumei1966@126.com.
Bi S; Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, People's Republic of China. bisai11@126.com.

J Nanobiotechnology ; 19(1): 288, 2021 Sep 26.

Article em En | MEDLINE | ID: mdl-34565382

Assuntos

Terapia Genética/métodos; MicroRNAs/genética; Nanotecnologia/métodos; RNA Interferente Pequeno; Animais; Apoptose; DNA/genética; Feminino; Transferência Ressonante de Energia de Fluorescência; Células HeLa; Células Hep G2; Humanos; Células MCF-7; Nanopartículas Metálicas; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Técnicas de Amplificação de Ácido Nucleico; Neoplasias do Colo do Útero/terapia; Fator A de Crescimento do Endotélio Vascular/genética

Palavras-chave

Cervical carcinoma; DNA nanotechnology; Gene therapy; miRNA; siRNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia Genética / Nanotecnologia / MicroRNAs / RNA Interferente Pequeno Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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