Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease.
Intern Med
; 61(8): 1225-1230, 2022 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-34565772
ABSTRACT
Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respectively. Transdermal isosorbide tape as a nitric oxide donor was applied to Patients 1 and 2 on post-transplantation days 60 and 66, respectively, which rapidly improved their jaundice after 1 day. This is the first report to describe the efficacy of transdermal isosorbide tape for adult patients with jaundice associated with TAM related to GVHD.
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MEDLINE
Assunto principal:
Doenças Vasculares
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Transplante de Células-Tronco Hematopoéticas
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Doença Enxerto-Hospedeiro
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Icterícia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article