Eugenol-acacia gum-based bifunctional nanofibers as a potent antifungal transdermal substitute.
Nanomedicine (Lond)
; 16(25): 2269-2289, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34569268
ABSTRACT
Aim:
Fungal biofilms interfere with the wound healing processes. Henceforth, the study aims to fabricate a biomaterial-based nano-scaffold with the dual functionalities of wound healing and antibiofilm activity.Methods:
Nanofibers comprising acacia gum, polyvinyl alcohol and inclusion complex of eugenol in ß-cyclodextrin (EG-NF) were synthesized using electrospinning. Antibiofilm studies were performed on Candida species, and the wound-healing activity was evaluated through an in vivo excision wound rat model.Results:
The EG-NF potentially eradicated the mature biofilm of Candida species and their clinical isolates. Further, EG-NF also enhanced the re-epithelization and speed of wound healing in in vivo rat experiments.Conclusion:
The study established the bifunctional applications of eugenol nanofibers as a transdermal substitute with antifungal potency.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nanofibras
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article