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EncephalApp Stroop Test validation for the screening of minimal hepatic encephalopathy in Brazil.
Cunha-Silva, Marlone; Neto, Fernando L Ponte; de Araújo, Priscila S; Pazinato, Lucas V; Greca, Raquel D; Secundo, Tirzah M L; Imbrizi, Marcello R; Monici, Leonardo T; Sevá-Pereira, Tiago; Mazo, Daniel F.
Afiliação
  • Cunha-Silva M; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil. Electronic address: marlone.cunha@hotmail.com.
  • Neto FLP; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil.
  • de Araújo PS; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil.
  • Pazinato LV; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil.
  • Greca RD; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil.
  • Secundo TML; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil.
  • Imbrizi MR; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil.
  • Monici LT; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil.
  • Sevá-Pereira T; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil.
  • Mazo DF; Division of Gastroenterology (Gastrocentro), University of Campinas (Unicamp), Campinas, Brazil; Division of Clinical Gastroenterology and Hepatology, Department of Gastroenterology, University of São Paulo School of Medicine (FMUSP), Sao Paulo, Brazil.
Ann Hepatol ; 27(1): 100543, 2022.
Article em En | MEDLINE | ID: mdl-34571266
INTRODUCTION AND OBJECTIVES: The EncephalApp Stroop Test was developed to more easily diagnose minimal hepatic encephalopathy (MHE). A cut-off of >274.9sec (ONtime+OFFtime) reached a 78% sensitivity and 90% specificity in the validation study, but it has been poorly studied in Brazil. We aim to analyze the usefulness of this diagnostic method and to describe a cut-off value to screen MHE in Brazil. METHODS: In this cross-sectional and single-center study, three positive psychometric tests defined the diagnosis of MHE as the gold standard. We evaluated gender, age, education, familiarity with smartphones, etiology of cirrhosis, Child-Pugh/MELD scores, and previous hepatic encephalopathy (HE). Healthy controls and patients without HE were compared for the task validation. The Chi-square and Mann-Whitney tests, logistic regression analysis, and ROC curves were used for statistical evaluation. RESULTS: We included 132 patients with cirrhosis (61% male) and 42 controls (62% male) around 51y. Sixty-three were diagnosed with MHE on psychometric tests and 23 had clinical HE. Viral hepatitis (38%) was the major etiology of cirrhosis. The median MELD was 10 and Child-Pugh A was more frequent (70%). There was no significant difference in test results between controls and patients without HE. There was also no influence of gender, age, education, and familiarity with smartphones in the test results. Child-Pugh A was associated with MHE (p=0.0106). A cut-off of >269.8sec (ONtime+OFFtime) had an 87% sensitivity and 77% specificity to detect MHE (p=0.002). CONCLUSION: This is a valid and reliable tool for screening MHE. However, optimal cut-off values need to be validated locally.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalopatia Hepática / Programas de Rastreamento / Cognição / Diagnóstico Precoce / Teste de Stroop Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalopatia Hepática / Programas de Rastreamento / Cognição / Diagnóstico Precoce / Teste de Stroop Idioma: En Ano de publicação: 2022 Tipo de documento: Article