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Expression and Clinical Utility of Transcription Factors Involved in Epithelial-Mesenchymal Transition during Thyroid Cancer Progression.
Baldini, Enke; Tuccilli, Chiara; Pironi, Daniele; Catania, Antonio; Tartaglia, Francesco; Di Matteo, Filippo Maria; Palumbo, Piergaspare; Arcieri, Stefano; Mascagni, Domenico; Palazzini, Giorgio; Tripodi, Domenico; Maturo, Alessandro; Vergine, Massimo; Tarroni, Danilo; Lori, Eleonora; Ferent, Iulia Catalina; De Vito, Corrado; Fallahi, Poupak; Antonelli, Alessandro; Censi, Simona; D'Armiento, Matteo; Barollo, Susy; Mian, Caterina; Morrone, Aldo; D'Andrea, Vito; Sorrenti, Salvatore; Ulisse, Salvatore.
Afiliação
  • Baldini E; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Tuccilli C; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Pironi D; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Catania A; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Tartaglia F; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Di Matteo FM; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Palumbo P; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Arcieri S; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Mascagni D; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Palazzini G; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Tripodi D; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Maturo A; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Vergine M; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Tarroni D; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Lori E; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Ferent IC; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • De Vito C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy.
  • Fallahi P; Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
  • Antonelli A; Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
  • Censi S; Department of Medicine, University of Padua, 35128 Padua, Italy.
  • D'Armiento M; Scientific Direction, IRCCS San Gallicano Dermatological Institute, 00144 Rome, Italy.
  • Barollo S; Department of Medicine, University of Padua, 35128 Padua, Italy.
  • Mian C; Department of Medicine, University of Padua, 35128 Padua, Italy.
  • Morrone A; Scientific Direction, IRCCS San Gallicano Dermatological Institute, 00144 Rome, Italy.
  • D'Andrea V; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Sorrenti S; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
  • Ulisse S; Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy.
J Clin Med ; 10(18)2021 Sep 09.
Article em En | MEDLINE | ID: mdl-34575184
The transcription factors involved in epithelial-mesenchymal transition (EMT-TFs) silence the genes expressed in epithelial cells (e.g., E-cadherin) while inducing those typical of mesenchymal cells (e.g., vimentin). The core set of EMT-TFs comprises Zeb1, Zeb2, Snail1, Snail2, and Twist1. To date, information concerning their expression profile and clinical utility during thyroid cancer (TC) progression is still incomplete. We evaluated the EMT-TF, E-cadherin, and vimentin mRNA levels in 95 papillary TC (PTC) and 12 anaplastic TC (ATC) tissues and correlated them with patients' clinicopathological parameters. Afterwards, we corroborated our findings by analyzing the data provided by a case study of the TGCA network. Compared with normal tissues, the expression of E-cadherin was found reduced in PTC and more strongly in ATC, while the vimentin expression did not vary. Among the EMT-TFs analyzed, Twist1 seems to exert a prominent role in EMT, being significantly associated with a number of PTC high-risk clinicopathological features and upregulated in ATC. Nonetheless, in the multivariate analysis, none of the EMT-TFs displayed a prognostic value. These data suggest that TC progression is characterized by an incomplete EMT and that Twist1 may represent a valuable therapeutic target warranting further investigation for the treatment of more aggressive thyroid cancers.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article