Quinazoline-tethered hydrazone: A versatile scaffold toward dual anti-TB and EGFR inhibition activities in NSCLC.

Emam, Aya M; Dahal, Achyut; Singh, Sitanshu S; Tosso, Rodrigo D; Ibrahim, Samy M; El-Sadek, Mohamed; Jois, Seetharama D; Enriz, Ricardo D; Kothayer, Hend

Emam, Aya M; Dahal, Achyut; Singh, Sitanshu S; Tosso, Rodrigo D; Ibrahim, Samy M; El-Sadek, Mohamed; Jois, Seetharama D; Enriz, Ricardo D; Kothayer, Hend.

Afiliação

Emam AM; Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Dahal A; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana, USA.
Singh SS; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana, USA.
Tosso RD; Pharmacy Department, Facultad de Química, Bioquímica y Farmacia, IMIBIO-CONICET, Universidad Nacional de San Luis, San Luis, Argentina.
Ibrahim SM; Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
El-Sadek M; Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Jois SD; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana, USA.
Enriz RD; Pharmacy Department, Facultad de Química, Bioquímica y Farmacia, IMIBIO-CONICET, Universidad Nacional de San Luis, San Luis, Argentina.
Kothayer H; Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Arch Pharm (Weinheim) ; 354(12): e2100281, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34585758

Assuntos

Antineoplásicos/farmacologia; Antituberculosos/farmacologia; Hidrazonas/farmacologia; Quinazolinas/farmacologia; Células A549; Antineoplásicos/síntese química; Antineoplásicos/química; Antituberculosos/síntese química; Antituberculosos/química; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Linhagem Celular Tumoral; Receptores ErbB/antagonistas & inibidores; Cloridrato de Erlotinib/farmacologia; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Humanos; Hidrazonas/síntese química; Hidrazonas/química; Neoplasias Pulmonares; Modelos Moleculares; Mycobacterium tuberculosis/efeitos dos fármacos; Quinazolinas/síntese química; Quinazolinas/química; Relação Estrutura-Atividade; Tuberculose/tratamento farmacológico

Palavras-chave

EGFR inhibitor; docking; dual anti-TB and anticancer; hydrazone; molecular dynamics simulations; quinazoline

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Hidrazonas / Antineoplásicos / Antituberculosos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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