Matrix stiffness drives stromal autophagy and promotes formation of a protumorigenic niche.

Hupfer, Anna; Brichkina, Anna; Koeniger, Anke; Keber, Corinna; Denkert, Carsten; Pfefferle, Petra; Helmprobst, Frederik; Pagenstecher, Axel; Visekruna, Alexander; Lauth, Matthias

Hupfer, Anna; Brichkina, Anna; Koeniger, Anke; Keber, Corinna; Denkert, Carsten; Pfefferle, Petra; Helmprobst, Frederik; Pagenstecher, Axel; Visekruna, Alexander; Lauth, Matthias.

Afiliação

Hupfer A; Center for Tumor and Immune Biology, Clinic of Gastroenterology, Endocrinology, Metabolism and Infectiology, Philipps University Marburg, Marburg, 35043, Germany.
Brichkina A; Center for Tumor and Immune Biology, Clinic of Gastroenterology, Endocrinology, Metabolism and Infectiology, Philipps University Marburg, Marburg, 35043, Germany.
Koeniger A; Center for Tumor and Immune Biology, Clinic of Gastroenterology, Endocrinology, Metabolism and Infectiology, Philipps University Marburg, Marburg, 35043, Germany.
Keber C; Institute of Pathology, Philipps University Marburg, Marburg, 35043, Germany.
Denkert C; Institute of Pathology, Philipps University Marburg, Marburg, 35043, Germany.
Pfefferle P; Biobank Core Facility, Philipps University Marburg, Marburg, 35043, Germany.
Helmprobst F; Electron Microscopy Core Facility, Department of Neuropathology, Philipps University Marburg, Marburg, 35043, Germany.
Pagenstecher A; Electron Microscopy Core Facility, Department of Neuropathology, Philipps University Marburg, Marburg, 35043, Germany.
Visekruna A; Institute of Medical Microbiology, Philipps University Marburg, Marburg, 35043, Germany.
Lauth M; Center for Tumor and Immune Biology, Clinic of Gastroenterology, Endocrinology, Metabolism and Infectiology, Philipps University Marburg, Marburg, 35043, Germany; lauth@staff.uni-marburg.de.

Proc Natl Acad Sci U S A ; 118(40)2021 10 05.

Article em En | MEDLINE | ID: mdl-34588305

Assuntos

Autofagia/fisiologia; Matriz Extracelular/patologia; Animais; Linhagem Celular; Matriz Extracelular/metabolismo; Fibroblastos/metabolismo; Fibroblastos/patologia; Fibrose/metabolismo; Fibrose/patologia; Adesões Focais/metabolismo; Adesões Focais/patologia; Integrina alfaV/metabolismo; Camundongos; Células NIH 3T3; Neoplasias/metabolismo; Neoplasias/patologia; Pâncreas/metabolismo; Pâncreas/patologia; Células Estromais/metabolismo

Palavras-chave

AMPK; ITGAV; autophagy; pancreatic stellate cells; tumor stroma

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Matriz Extracelular Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Matriz Extracelular Idioma: En Ano de publicação: 2021 Tipo de documento: Article