MEK/ERK MAP kinase limits poly I:C-induced antiviral gene expression in RAW264.7 macrophages by reducing interferon-beta expression.
FEBS Lett
; 595(21): 2665-2674, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34591979
ABSTRACT
Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (or the synthetic dsRNA analog poly IC) and induces a signal transduction pathway that results in activation of transcription factors that induce expression of antiviral genes including type I interferon (IFN-I). Secreted IFN-I positively feeds back to amplify antiviral gene expression. In this report, we study the role of MEK/ERK MAP kinase in modulating antiviral gene expression downstream of TLR3. We find MEK/ERK is a negative regulator of antiviral gene expression by limiting expression of IFN-ß. However, MEK/ERK does not limit antiviral responses downstream of the type I interferon receptor. These findings provide insights into regulatory mechanisms of antiviral gene expression and reveal potential targets for modulating antiviral immunity.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Interferon beta
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MAP Quinases Reguladas por Sinal Extracelular
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article