The Role of Serum Tumor Markers in Follow-up After Surgical Treatment of Malignant Lung Tumors.
Anticancer Res
; 41(10): 5117-5122, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34593462
ABSTRACT
AIM:
The aim of this study was to evaluate the utility of selected tumor markers for the detection of lung cancer recurrence during follow-up. PATIENTS ANDMETHODS:
The study group consisted of 109 patients and 109 healthy controls. The following biomarkers were selected Carcinoembryonic antigen; cytokeratin fragment 19; neuron-specific enolase; tissue polypeptide-specific antigen; cytokeratin fragments 8, 18 and 19; insulin-like growth factor 1; pro-gastrin-releasing peptide; and 25-hydroxyvitamin D. The biomarkers were assessed individually or using a multivariate analysis.RESULTS:
Carcinoembryonic antigen [area under the receiver operating characteristics curve (AUC)=0.6857, p<0.0001] and cytokeratin fragment 19 (AUC=0.6882, p<0.0001) proved best in detecting relapse. The multivariate model indicated insulin-like growth factor 1 (p=0.0006, AUC=0.6225) as the third most useful biomarker. The multivariate model using these three markers achieved the best AUC value of 0.7730 (p=0.0050).CONCLUSION:
We demonstrated that carcinoembryonic antigen and cytokeratin fragment 19 play a key role in the detection of lung cancer recurrence. A multivariate approach can increase the effectiveness of detection.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonectomia
/
Carcinoma de Células Escamosas
/
Biomarcadores Tumorais
/
Carcinoma Pulmonar de Células não Pequenas
/
Adenocarcinoma de Pulmão
/
Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article