Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.

Zhu, Manhui; Wang, Ying; Zhu, Linling; Du, Shu; Wang, Zhenzhen; Zhang, Yuting; Guo, Yang; Tu, Yuanyuan; Song, E

Zhu, Manhui; Wang, Ying; Zhu, Linling; Du, Shu; Wang, Zhenzhen; Zhang, Yuting; Guo, Yang; Tu, Yuanyuan; Song, E.

Afiliação

Zhu M; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Wang Y; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhu L; Department of Ophthalmology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Du S; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Wang Z; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhang Y; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Guo Y; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Tu Y; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Song E; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China. tuyuanyuaneye@163.com.

Inflammation ; 45(1): 414-427, 2022 Feb.

Article em En | MEDLINE | ID: mdl-34595678

Assuntos

Corioide/metabolismo; Neovascularização de Coroide/metabolismo; Células Endoteliais/metabolismo; Inflamassomos/metabolismo; Piroptose; Epitélio Pigmentado da Retina/metabolismo; Anexina A1/metabolismo; Biomarcadores/metabolismo; Linhagem Celular; Humanos; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Proteína Tirosina Fosfatase não Receptora Tipo 11/metabolismo; Receptores de Formil Peptídeo/metabolismo; Receptores de Lipoxinas/metabolismo

Palavras-chave

Age-related macular degeneration (AMD); Annexin A1 (ANXA1); Choroidal endothelial cells (CECs); Choroidal neovascularization (CNV); Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome; Retinal pigment epithelial (RPE) cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corioide / Neovascularização de Coroide / Células Endoteliais / Epitélio Pigmentado da Retina / Inflamassomos / Piroptose Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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