Rac1/pSTAT3 expression: A pharmacodynamic marker panel as a first step toward optimization of thiopurine therapy in inflammatory bowel disease patients.

Deben, Debbie S; van Adrichem, Arjan J; Drent, Roosmarie; Puts, Sabine; Pelzer, Kelly E J M; van Bodegraven, Adriaan A; Wong, Dennis R; Leers, Mathie P G

Deben, Debbie S; van Adrichem, Arjan J; Drent, Roosmarie; Puts, Sabine; Pelzer, Kelly E J M; van Bodegraven, Adriaan A; Wong, Dennis R; Leers, Mathie P G.

Afiliação

Deben DS; Department of Clinical Pharmacy, Clinical pharmacology and Toxicology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.
van Adrichem AJ; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.
Drent R; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.
Puts S; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.
Pelzer KEJM; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.
van Bodegraven AA; Department of Gastroenterology, Geriatrics, Internal and Intensive Care Medicine (Co-MIK), Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.
Wong DR; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Leers MPG; Department of Clinical Pharmacy, Clinical pharmacology and Toxicology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.

Cytometry A ; 101(2): 167-176, 2022 02.

Article em En | MEDLINE | ID: mdl-34595833

Assuntos

Doenças Inflamatórias Intestinais; Mercaptopurina; Azatioprina/farmacologia; Azatioprina/uso terapêutico; Biomarcadores; Humanos; Imunossupressores/uso terapêutico; Doenças Inflamatórias Intestinais/tratamento farmacológico; Doenças Inflamatórias Intestinais/metabolismo; Mercaptopurina/farmacologia; Mercaptopurina/uso terapêutico; Linfócitos T/metabolismo; Proteínas rac1 de Ligação ao GTP/metabolismo

Palavras-chave

Rac1; inflammatory bowel diseases; multiparameter flow cytometry; pSTAT3; pharmacodynamics; thiopurines

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Mercaptopurina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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