MungeSumstats: a Bioconductor package for the standardization and quality control of many GWAS summary statistics.
Bioinformatics
; 37(23): 4593-4596, 2021 12 07.
Article
em En
| MEDLINE
| ID: mdl-34601555
ABSTRACT
MOTIVATION Genome-wide association studies (GWAS) summary statistics have popularized and accelerated genetic research. However, a lack of standardization of the file formats used has proven problematic when running secondary analysis tools or performing meta-analysis studies. RESULTS:
To address this issue, we have developed MungeSumstats, a Bioconductor R package for the standardization and quality control of GWAS summary statistics. MungeSumstats can handle the most common summary statistic formats, including variant call format (VCF) producing a reformatted, standardized, tabular summary statistic file, VCF or R native data object. AVAILABILITY AND IMPLEMENTATION MungeSumstats is available on Bioconductor (v 3.13) and can also be found on Github at https//neurogenomics.github.io/MungeSumstats. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
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Base de dados:
MEDLINE
Assunto principal:
Software
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Estudo de Associação Genômica Ampla
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article