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Solid tumor size for prediction of recurrence in large and giant non-functioning pituitary adenomas.
Ko, Ching-Chung; Chang, Chin-Hong; Chen, Tai-Yuan; Lim, Sher-Wei; Wu, Te-Chang; Chen, Jeon-Hor; Kuo, Yu-Ting.
Afiliação
  • Ko CC; Department of Medical Imaging, Chi-Mei Medical Center, Tainan, Taiwan. kocc0729@gmail.com.
  • Chang CH; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan. kocc0729@gmail.com.
  • Chen TY; Department of Neurosurgery, Chi Mei Medical Center, Tainan, Taiwan.
  • Lim SW; Department of Medical Imaging, Chi-Mei Medical Center, Tainan, Taiwan.
  • Wu TC; Graduate Institute of Medical Sciences, Chang Jung Christian University, Tainan, Taiwan.
  • Chen JH; Department of Neurosurgery, Chi-Mei Medical Center, Chiali, Tainan, Taiwan.
  • Kuo YT; Department of Nursing, Min-Hwei College of Health Care Management, Tainan, Taiwan.
Neurosurg Rev ; 45(2): 1401-1411, 2022 Apr.
Article em En | MEDLINE | ID: mdl-34606021
ABSTRACT
A subset of large non-functioning pituitary adenomas (lNFPA) and giant non-functioning pituitary adenomas (gNFPA) undergoes early progression/recurrence (P/R) after surgery. This study revealed the clinical and image predictors of P/R in lNFPA and gNFPA, with emphasis on solid tumor size. This retrospective study investigated the preoperative MR imaging features for the prediction of P/R in lNFPA (> 3 cm) and gNFPA (> 4 cm). Only the patients with a complete preoperative brain MRI and undergone postoperative MRI follow-ups for more than 1 year were included. From November 2010 to December 2020, a total of 34 patients diagnosed with lNFPA and gNFPA were included (median follow-up time 47.6 months) in this study. A total of twenty-three (23/34, 67.6%) patients had P/R, and the median time to P/R is 25.2 months. Solid tumor diameter (STD), solid tumor volume (STV), and extent of resection are associated with P/R (p < 0.05). Multivariate analysis showed large STV is a risk factor for P/R (p < 0.05) with a hazard ratio of 30.79. The cutoff points of STD and STV for prediction of P/R are 26 mm and 7.6 cm3, with AUCs of 0.78 and 0.79 respectively. Kaplan-Meier analysis of tumor P/R trends showed that patients with larger STD and STV exhibited shorter progression-free survival (p < 0.05). For lNFPA and gNFPA, preoperative STD and STV are significant predictors of P/R. The results offer objective and valuable information for treatment planning in this subgroup.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Hipofisárias / Adenoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Hipofisárias / Adenoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article