Versatile Access to Tetrasubstituted 2-Amidoacroleins through Formal Silylformylation of Ynamides.
Org Lett
; 23(20): 8093-8097, 2021 10 15.
Article
em En
| MEDLINE
| ID: mdl-34612044
ABSTRACT
In this paper we are reporting the first regio- and stereoselective silylformylation of ynamides. This reaction is tolerant to a wide range of functional groups around the ynamides. The substitution of CO by an isocyanide makes this reaction safer and more practical than standard silylformylation reactions. It overall represents a versatile and rapid access to various tetrasubstituted 3-silyl-2-amidoacrolein derivatives. The synthetic potential of these new building blocks has been evaluated by performing several postfunctionalization.
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MEDLINE
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En
Ano de publicação:
2021
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Article