Joint Clustering of Single-Cell Sequencing and Fluorescence In Situ Hybridization Data for Reconstructing Clonal Heterogeneity in Cancers.

Fu, Xuecong; Lei, Haoyun; Tao, Yifeng; Heselmeyer-Haddad, Kerstin; Torres, Irianna; Dean, Michael; Ried, Thomas; Schwartz, Russell

Fu, Xuecong; Lei, Haoyun; Tao, Yifeng; Heselmeyer-Haddad, Kerstin; Torres, Irianna; Dean, Michael; Ried, Thomas; Schwartz, Russell.

Afiliação

Fu X; Department of Biological Sciences, and Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Lei H; Computational Biology Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Tao Y; Computational Biology Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Heselmeyer-Haddad K; Genetics Branch, Cancer Genomics Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Torres I; Genetics Branch, Cancer Genomics Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Dean M; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.
Ried T; Genetics Branch, Cancer Genomics Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Schwartz R; Department of Biological Sciences, and Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.

J Comput Biol ; 28(11): 1035-1051, 2021 11.

Article em En | MEDLINE | ID: mdl-34612714

Assuntos

Neoplasias Encefálicas/genética; Biologia Computacional/métodos; Glioblastoma/genética; Hibridização in Situ Fluorescente/métodos; Análise de Célula Única/métodos; Anáfase; Aneuploidia; Evolução Clonal; Análise por Conglomerados; Evolução Molecular; Humanos; Cadeias de Markov; Método de Monte Carlo; Filogenia; Análise de Sequência de RNA

Palavras-chave

cancer; clonal evolution; sequencing; single-cell genomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Hibridização in Situ Fluorescente / Glioblastoma / Biologia Computacional / Análise de Célula Única Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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