Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats.

González, Eduardo A; Calsbeek, Jonas J; Tsai, Yi-Hua; Tang, Mei-Yun; Andrew, Peter; Vu, Joan; Berg, Elizabeth L; Saito, Naomi H; Harvey, Danielle J; Supasai, Suangsuda; Gurkoff, Gene G; Silverman, Jill L; Lein, Pamela J

González, Eduardo A; Calsbeek, Jonas J; Tsai, Yi-Hua; Tang, Mei-Yun; Andrew, Peter; Vu, Joan; Berg, Elizabeth L; Saito, Naomi H; Harvey, Danielle J; Supasai, Suangsuda; Gurkoff, Gene G; Silverman, Jill L; Lein, Pamela J.

Afiliação

González EA; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Calsbeek JJ; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Tsai YH; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Tang MY; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Andrew P; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Vu J; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Berg EL; Department of Psychiatry, University of California, Davis, School of Medicine, 2230, Stockton Boulevard, Sacramento, CA 95817, USA.
Saito NH; Department of Public Health Sciences, University of California, Davis, One Shields Avenue, School of Medicine, Davis, CA 95616, USA.
Harvey DJ; Department of Public Health Sciences, University of California, Davis, One Shields Avenue, School of Medicine, Davis, CA 95616, USA.
Supasai S; Department of Molecular Biosciences, University of California, Davis, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA.
Gurkoff GG; Department of Neurological Surgery, University of California, Davis, School of Medicine, 4860 Y Street, Sacramento, CA 95817, USA.
Silverman JL; Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95618, USA.
Lein PJ; Department of Psychiatry, University of California, Davis, School of Medicine, 2230, Stockton Boulevard, Sacramento, CA 95817, USA.

Curr Res Toxicol ; 2: 341-356, 2021.

Article em En | MEDLINE | ID: mdl-34622217

Palavras-chave

2-PAM, pralidoxime; AChE, acetylcholinesterase; AS, atropine-sulfate; BChE, butyrylcholinesterase; CT, computed tomography; ChE, cholinesterase; Cognitive deficits; DFP, diisopropylfluorophosphate; EEG, electroencephalogram; FJC, Fluoro-Jade C; Neurodegeneration; Neurogenesis; Neuroinflammation; OP, organophosphate; PBS, phosphate-buffered saline; ROI, region of interest; SE, status epilepticus; Seizures; Sex differences; T2w, T2-weighted; VEH, vehicle; i.m., intramuscular; i.p., intraperitoneal; s.c., subcutaneous

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article