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Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models.
Burbulla, Lena F; Zheng, Jianbin; Song, Pingping; Jiang, Weilan; Johnson, Michaela E; Brundin, Patrik; Krainc, Dimitri.
Afiliação
  • Burbulla LF; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Zheng J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Song P; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig Maximilians University, Munich, Germany.
  • Jiang W; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Johnson ME; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Brundin P; Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois, USA.
  • Krainc D; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
JCI Insight ; 6(19)2021 10 08.
Article em En | MEDLINE | ID: mdl-34622801
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Antipsicóticos / Transtornos Parkinsonianos / Alfa-Sinucleína / Neurônios Dopaminérgicos / Fumarato de Quetiapina / Glucosilceramidase Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Antipsicóticos / Transtornos Parkinsonianos / Alfa-Sinucleína / Neurônios Dopaminérgicos / Fumarato de Quetiapina / Glucosilceramidase Idioma: En Ano de publicação: 2021 Tipo de documento: Article