Segregation of nuclear and membrane-initiated actions of estrogen receptor using genetically modified animals and pharmacological tools.
Mol Cell Endocrinol
; 539: 111467, 2022 01 01.
Article
em En
| MEDLINE
| ID: mdl-34626731
ABSTRACT
Estrogen receptor alpha (ERα) and beta (ERß) are members of the nuclear receptor superfamily, playing widespread functions in reproductive and non-reproductive tissues. Beside the canonical function of ERs as nuclear receptors, in this review, we summarize our current understanding of extra-nuclear, membrane-initiated functions of ERs with a specific focus on ERα. Over the last decade, in vivo evidence has accumulated to demonstrate the physiological relevance of this ERα membrane-initiated-signaling from mouse models to selective pharmacological tools. Finally, we discuss the perspectives and future challenges opened by the integration of extra-nuclear ERα signaling in physiology and pathology of estrogens.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Núcleo Celular
/
Receptor alfa de Estrogênio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article