Integrative eQTL-weighted hierarchical Cox models for SNP-set based time-to-event association studies.

Lu, Haojie; Wei, Yongyue; Jiang, Zhou; Zhang, Jinhui; Wang, Ting; Huang, Shuiping; Zeng, Ping

Lu, Haojie; Wei, Yongyue; Jiang, Zhou; Zhang, Jinhui; Wang, Ting; Huang, Shuiping; Zeng, Ping.

Afiliação

Lu H; Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Wei Y; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
Jiang Z; Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Zhang J; Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Wang T; Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Huang S; Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Zeng P; Center for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.

J Transl Med ; 19(1): 418, 2021 10 09.

Article em En | MEDLINE | ID: mdl-34627275

Assuntos

Estudo de Associação Genômica Ampla; Locos de Características Quantitativas; Humanos; Fenótipo; Polimorfismo de Nucleotídeo Único/genética; Modelos de Riscos Proporcionais; Locos de Características Quantitativas/genética

Palavras-chave

Aggregated Cauchy association test; Cox model; Expression quantitative trait loci; Hierarchical modeling; Integrative analysis; Joint effect test; SNP-set association study

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Locos de Características Quantitativas / Estudo de Associação Genômica Ampla Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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