Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information.

Osteosarcoma is a devastating condition that is prevalent in the Irish Wolfhound breed. In this study, our aim was to estimate heritability of osteosarcoma in the Irish Wolfhound breed. We undertook a pedigree-based analysis to estimate heritability of osteosarcoma in the Irish Wolfhound. The pedigree used included 5110 pure-bred Irish Wolfhounds, including 332 dogs diagnosed with osteosarcoma and 360 control dogs. We considered dogs to be controls if they were over 10 years of age and were not reported to have developed osteosarcoma. This study found the heritability estimate of osteosarcoma in the Irish Wolfhound to be 0.65. This score means that osteosarcoma in this breed is: 1) highly heritable and 2) a complex trait, which means that both environmental and genetic factors influence disease risk. Overall, our results provide support for further investigation into the genetic variants involved in the development of osteosarcoma in Irish Wolfhounds.