ROX index as predictor of high flow nasal cannula therapy success in acute respiratory failure due to SARS-CoV-2.
Respir Med
; 189: 106638, 2021.
Article
em En
| MEDLINE
| ID: mdl-34634500
ABSTRACT
BACKGROUND:
High-Flow Nasal Cannula (HFNC) therapy is useful treatment in patients with acute respiratory failure (ARF). The ROX index (ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate) has been evaluated to predict success of HFNC in patients with pneumonia.OBJECTIVE:
The aim of this study was to determine whether the ROX Index could predict HFNC therapy success in patients with ARF due to SARS-CoV-2 pneumonia.METHODS:
An observational, prospective study was performed including patients admitted with ARF secondary to SARS-CoV-2 pneumonia who met criteria for HFNC therapy initiation. Demographic, radiological, laboratory and clinical course data were collected. The ROX index was calculated at 1 h, 6 h, 12 h and 24 h after starting HFNC.RESULTS:
In total 85 patients were included (age, 64.51 + 11.78 years; male, 69.4%). HFNC failed in 47 (55.3%) patients, of whom 45 (97.8%) were initially managed with noninvasive ventilation (NIV). ROX index at 24 h was the best predictor of HFNC success (AUC 0.826, 95%CI 0.593-1.00, p = 0.015) with a cut-off point of 5.35 (S 0.91, Sp 0.79, PPV 0.92, NPP 0.79). In multivariate logistic regression analysis ROX index at 24 h proved the best predictor of HFNC success.CONCLUSIONS:
ROX index at 24 h with a cut-off point of 5.35 predicts HFNC success in patients with SARS-Cov-2-induced ARF.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Oxigenoterapia
/
Insuficiência Respiratória
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Oximetria
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Taxa Respiratória
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COVID-19
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article