Utility of a pharmacogenetic-driven algorithm in guiding dual antiplatelet therapy for patients undergoing coronary drug-eluting stent implantation in China.

Lyu, Si-Qi; Zhu, Jun; Wang, Juan; Wu, Shuang; Zhang, Han; Shao, Xing-Hui; Yang, Yan-Min

Lyu, Si-Qi; Zhu, Jun; Wang, Juan; Wu, Shuang; Zhang, Han; Shao, Xing-Hui; Yang, Yan-Min.

Afiliação

Lyu SQ; Emergency and Critical Care Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, People's Republic of China.
Zhu J; Emergency and Critical Care Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, People's Republic of China.
Wang J; Emergency and Critical Care Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, People's Republic of China.
Wu S; Emergency and Critical Care Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, People's Republic of China.
Zhang H; Emergency and Critical Care Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, People's Republic of China.
Shao XH; Emergency and Critical Care Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, People's Republic of China.
Yang YM; Emergency and Critical Care Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, People's Republic of China. yymfuwa

Eur J Clin Pharmacol ; 78(2): 215-225, 2022 Feb.

Article em En | MEDLINE | ID: mdl-34636928

Assuntos

Povo Asiático/genética; Citocromo P-450 CYP2C19/genética; Stents Farmacológicos; Terapia Antiplaquetária Dupla/efeitos adversos; Hemorragia/induzido quimicamente; Inibidores da Agregação Plaquetária/efeitos adversos; Idoso; Algoritmos; Aspirina/uso terapêutico; Doenças Cardiovasculares; China; Clopidogrel/uso terapêutico; Comorbidade; Terapia Antiplaquetária Dupla/métodos; Feminino; Comportamentos Relacionados com a Saúde; Humanos; Masculino; Pessoa de Meia-Idade; Farmacogenética; Antagonistas do Receptor Purinérgico P2Y/efeitos adversos; Medição de Risco; Fatores de Risco; Fatores Sociodemográficos; Ticagrelor; Ticlopidina/uso terapêutico

Palavras-chave

CYP2C19 genotype; Drug-eluting stent implantation; Major adverse cardiovascular events; Platelet reactivity; Tailored antiplatelet therapy; The POPular Risk Score

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Povo Asiático / Stents Farmacológicos / Citocromo P-450 CYP2C19 / Terapia Antiplaquetária Dupla / Hemorragia Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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