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Overview and emerging trends in optical fiber aptasensing.
Loyez, Médéric; DeRosa, Maria C; Caucheteur, Christophe; Wattiez, Ruddy.
Afiliação
  • Loyez M; Proteomics and Microbiology Department, University of Mons, Avenue du Champ de Mars 6, 7000, Mons, Belgium; Electromagnetism and Telecommunication Department, University of Mons, Bld. Dolez 31, 7000, Mons, Belgium. Electronic address: mederic.loyez@umons.ac.be.
  • DeRosa MC; Department of Chemistry, 203 Steacie Building, Carleton University, 1125, Colonel By Drive, Ottawa, ON K1S 5B6, Canada.
  • Caucheteur C; Electromagnetism and Telecommunication Department, University of Mons, Bld. Dolez 31, 7000, Mons, Belgium.
  • Wattiez R; Proteomics and Microbiology Department, University of Mons, Avenue du Champ de Mars 6, 7000, Mons, Belgium.
Biosens Bioelectron ; 196: 113694, 2022 Jan 15.
Article em En | MEDLINE | ID: mdl-34637994
Optical fiber biosensors have attracted growing interest over the last decade and quickly became a key enabling technology, especially for the detection of biomarkers at extremely low concentrations and in small volumes. Among the many and recent fiber-optic sensing amenities, aptamers-based sensors have shown unequalled performances in terms of ease of production, specificity, and sensitivity. The immobilization of small and highly stable bioreceptors such as DNA has bolstered their use for the most varied applications e.g., medical diagnosis, food safety and environmental monitoring. This review highlights the recent advances in aptamer-based optical fiber biosensors. An in-depth analysis of the literature summarizes different fiber-optic structures and biochemical strategies for molecular detection and immobilization of receptors over diverse surfaces. In this review, we analyze the features offered by those sensors and discuss about the next challenges to be addressed. This overview investigates both biochemical and optical parameters, drawing the guiding lines for forthcoming innovations and prospects in this ever-growing field of research.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / Aptâmeros de Nucleotídeos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / Aptâmeros de Nucleotídeos Idioma: En Ano de publicação: 2022 Tipo de documento: Article