Difluoromethyl Radical Triggered Tandem Reaction of N-Allyl Amides to Difluoromethylated ß-Amino Alcohols by Photoredox Catalysis.
Org Lett
; 23(21): 8482-8487, 2021 11 05.
Article
em En
| MEDLINE
| ID: mdl-34641687
ABSTRACT
An elegant tandem reaction process for transferring N-allyl amide into CF2H-ß-amino alcohol is described. This approach proceeded smoothly under visible light irradiation in the presence of a 3 mol % Ir complex, exhibiting a broad substrate scope and functional group tolerance, and a variety of CF2H-ß-amino alcohols were readily accessed in good to excellent yields under mild conditions. The reliable mechanistic studies revealed that sequential difluoromethyl radical addition/carbocation trap/rearrangement is involved.
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MEDLINE
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En
Ano de publicação:
2021
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Article