Anisotropic Particles through Multilayer Assembly.
Macromol Biosci
; 22(1): e2100328, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34644008
ABSTRACT
The anisotropy in the shape of polymeric particles has been demonstrated to have many advantages over spherical particulates, including bio-mimetic behavior, shaped-directed flow, deformation, surface adhesion, targeting, motion, and permeability. The layer-by-layer (LbL) assembly is uniquely suited for synthesizing anisotropic particles as this method allows for simple and versatile replication of diverse colloid geometries with precise control over their chemical and physical properties. This review highlights recent progress in anisotropic particles of micrometer and nanometer sizes produced by a templated multilayer assembly of synthetic and biological macromolecules. Synthetic approaches to produce capsules and hydrogels utilizing anisotropic templates such as biological, polymeric, bulk hydrogel, inorganic colloids, and metal-organic framework crystals as sacrificial templates are overviewed. Structure-property relationships controlled by the anisotropy in particle shape and surface are discussed and compared with their spherical counterparts. Advances and challenges in controlling particle properties through varying shape anisotropy and surface asymmetry are outlined. The perspective applications of anisotropic colloids in biomedicine, including programmed behavior in the blood and tissues as artificial cells, nano-motors/sensors, and intelligent drug carriers are also discussed.
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Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Portadores de Fármacos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article