Evaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats.
Acta Cir Bras
; 36(8): e360805, 2021.
Article
em En
| MEDLINE
| ID: mdl-34644773
ABSTRACT
PURPOSE:
The present study aimed at testing a new formulation of mesalazine linked to chondroitin sulfate and its components alone in the treatment of actinic proctitis in rats.METHODS:
Forty-seven female Wistar rats were submitted to pelvic radiation and divided into eight groups control A, mesalazine A, chondroitin A, and conjugate A, gavage of the according substance two weeks after irradiation and sacrifice three weeks after oral treatment; control C, mesalazine C, chondroitin C, and conjugate C, sacrifice six weeks after oral treatment. The rectum was submitted to histological characterization for each of thefindings:
inflammatory infiltrate, epithelial degeneration, mucosal necrosis, and fibrosis.RESULTS:
The inflammatory infiltrate was more intense in chondroitin A, mesalazine A, and conjugate C. The collagen deposition was less intense in chondroitin A, and mesalazine A, and more intense in control C.CONCLUSIONS:
Mesalazine and chondroitin alone were efficacious in inducing a delayed inflammatory response, hence reducing the late fibrosis. The conjugate was able to induce an ever more delayed inflammatory response.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proctite
/
Colite Ulcerativa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article