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Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation.
Yang, Chengbin; Lu, Mingzhu; Chen, Yi; Xiang, Ruiqing; Qiu, Tianze; Jia, Yu; Yang, Yongtai; Liu, Xiaofeng; Deng, Mingli; Ling, Yun; Zhou, Yaming.
Afiliação
  • Yang C; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Lu M; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Chen Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Xiang R; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Qiu T; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Jia Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Yang Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Liu X; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Deng M; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Ling Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
  • Zhou Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China. Electronic address: ymzhou@fudan.edu.cn.
Bioorg Chem ; 117: 105405, 2021 12.
Article em En | MEDLINE | ID: mdl-34649154
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase / Indóis / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase / Indóis / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article