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Multivariate alterations in insula - Medial prefrontal cortex linked to genetics in 12q24 in schizophrenia.
Jiang, Wenhao; Rootes-Murdy, Kelly; Chen, Jiayu; Bizzozero, Nora I Perrone-; Calhoun, Vince D; van Erp, Theo G M; Ehrlich, Stefan; Agartz, Ingrid; Jönsson, Erik G; Andreassen, Ole A; Wang, Lei; Pearlson, Godfrey D; Glahn, David C; Hong, Elliot; Liu, Jingyu; Turner, Jessica A.
Afiliação
  • Jiang W; Department of Psychology, Georgia State University, United States of America; Department of Psychosomatics and Psychiatry, Zhongda Hospital, Institute of Psychosomatics, Medical School, Southeast University, Nanjing, China.
  • Rootes-Murdy K; Department of Psychology, Georgia State University, United States of America.
  • Chen J; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, United States of America.
  • Bizzozero NIP; Department of Neurosciences, University of New Mexico, United States of America.
  • Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, United States of America.
  • van Erp TGM; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, United States of America; Qureshey Research Laboratory, Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA,United States of Ameri
  • Ehrlich S; Department of Psychiatry, Massachusetts General Hospital, United States of America; Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany.
  • Agartz I; NORMENT, Institute of Clinical Medicine, University of Oslo, Norway; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo,
  • Jönsson EG; NORMENT, Institute of Clinical Medicine, University of Oslo, Norway; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
  • Andreassen OA; NORMENT, Institute of Clinical Medicine, University of Oslo, Norway.
  • Wang L; Psychiatry and Behavioral Health, Ohio State Wexner Medical Center, United States of America.
  • Pearlson GD; Department of Psychiatry, Yale University, United States of America.
  • Glahn DC; Boston Children's Hospital and Harvard Medical School, United States of America.
  • Hong E; Maryland Psychiatric Research Center, University of Maryland School of Medicine, United States of America.
  • Liu J; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, United States of America.
  • Turner JA; Department of Psychology, Georgia State University, United States of America; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, United States of America.
Psychiatry Res ; 306: 114237, 2021 12.
Article em En | MEDLINE | ID: mdl-34655926
ABSTRACT
The direct effect of genetic variations on clinical phenotypes within schizophrenia (SZ) remains elusive. We examined the previously identified association of reduced gray matter concentration in the insula - medial prefrontal cortex and a quantitative trait locus located in 12q24 in a SZ dataset. The main analysis was performed on 1461 SNPs and 830 participants. The highest contributing SNPs were localized in five genes including TMEM119, which encodes a microglial marker, that is associated with neuroinflammation and Alzheimer's disease. The gene set in 12q4 may partially explain brain alterations in SZ, but they may also relate to other psychiatric and developmental disorders.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia Idioma: En Ano de publicação: 2021 Tipo de documento: Article