Current Understanding toward Isonitrile Group Biosynthesis and Mechanism.
Chin J Chem
; 39(2): 463-472, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-34658601
ABSTRACT
Isonitrile group has been identified in many natural products. Due to the broad reactivity of N≡C triple bond, these natural products have valuable pharmaceutical potentials. This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile-containing natural product generation. Based on the strategies utilized, two fundamentally distinctive approaches are discussed. In addition, recent progress in elucidating isonitrile group formation mechanisms is also presented.
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MEDLINE
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En
Ano de publicação:
2021
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Article