Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells.

Islam, Atikul; Hsieh, Pei-Fang; Liu, Pei-Fen; Chou, Jou-Chun; Liao, Jiunn-Wang; Hsieh, Ming-Kun; Chueh, Pin Ju.

Afiliação

Islam A; Institute of Biomedical Sciences, National Chung Hsing University Taichung 40227, Taiwan.
Hsieh PF; Institute of Biomedical Sciences, National Chung Hsing University Taichung 40227, Taiwan.
Liu PF; Graduate Institute of Microbiology and Public Health, National Chung Hsing University Taichung 40227, Taiwan.
Chou JC; Department of Food Science and Biotechnology, National Chung Hsing University Taichung 40227, Taiwan.
Liao JW; Institute of Biomedical Sciences, National Chung Hsing University Taichung 40227, Taiwan.
Hsieh MK; Graduate Institute of Veterinary Pathobiology, National Chung Hsing University Taichung 40227, Taiwan.
Chueh PJ; Graduate Institute of Microbiology and Public Health, National Chung Hsing University Taichung 40227, Taiwan.

Am J Cancer Res ; 11(9): 4199-4219, 2021.

Article em En | MEDLINE | ID: mdl-34659883

Palavras-chave

Autophagy; CETSA-pulse proteolysis; cellular thermal shift assay (CETSA); melanoma; reactive oxygen species (ROS); sirtuin 1 (silent mating type information regulation 2 homolog 1 or SIRT1); tumor-associated NADH oxidase (tNOX or ENOX2)

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article