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Eleven new C19-diterpenoid alkaloids from Delphinium elatum cv. Pacific Giant.
Yamashita, Hiroshi; Doi, Nozomi; Hanawa, Nana; Itoh, Manami; Nakano, Wataru; Takahashi, Eri; Mizukami, Megumi; Kaneda, Kyousuke; Suzuki, Yuji; Goto, Masuo; Lee, Kuo-Hsiung; Wada, Koji.
Afiliação
  • Yamashita H; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 4-1, 7-jo 15-choume, Maeda, Teine-ku, Sapporo, 006-8585, Japan.
  • Doi N; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 4-1, 7-jo 15-choume, Maeda, Teine-ku, Sapporo, 006-8585, Japan.
  • Hanawa N; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 4-1, 7-jo 15-choume, Maeda, Teine-ku, Sapporo, 006-8585, Japan.
  • Itoh M; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 4-1, 7-jo 15-choume, Maeda, Teine-ku, Sapporo, 006-8585, Japan.
  • Nakano W; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 4-1, 7-jo 15-choume, Maeda, Teine-ku, Sapporo, 006-8585, Japan.
  • Takahashi E; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 4-1, 7-jo 15-choume, Maeda, Teine-ku, Sapporo, 006-8585, Japan.
  • Mizukami M; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 4-1, 7-jo 15-choume, Maeda, Teine-ku, Sapporo, 006-8585, Japan.
  • Kaneda K; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 4-1, 7-jo 15-choume, Maeda, Teine-ku, Sapporo, 006-8585, Japan.
  • Suzuki Y; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 4-1, 7-jo 15-choume, Maeda, Teine-ku, Sapporo, 006-8585, Japan.
  • Goto M; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599-7568, USA.
  • Lee KH; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599-7568, USA.
  • Wada K; Chinese Medicine Research and Development Center, China Medical University and Hospital, Taizhong, Taiwan.
J Nat Med ; 76(1): 161-170, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34669108
Diterpenoid alkaloids, the main components of plants of the genera Aconitum, Delphinium, and Garrya, are a group of natural products with notable chemical properties and biological activities. Several C19-diterpenoid alkaloid components from Delphinium elatum cv. Pacific Giant, as well as their derivatives, exhibited cytotoxic activity against lung, prostate, cervical, and vincristine-resistant cervical cancer cell lines. In the current phytochemical investigation on the seeds of D. elatum cv. Pacific Giant, eleven new C19-diterpenoid alkaloids, elapaciline (1), meladine (2), melapacitine (3), iminoeladine (4), 19-oxopaciline (5), 19-oxopacinine (6), N-deethyldelpheline (7), N-deethylpacinine (8), N-deethyl-19-oxoeladine (9), N-deethyl-N-formyleladine (10), and N-deethyl-N-formyldelpheline (11), together with 15 known C19-diterpenoid alkaloids were isolated. Their structures were elucidated by extensive spectroscopic methods including NMR (1D and 2D), IR, and MS (HRMS). Three known diterpenoid alkaloids, 6-dehydrodelcorine (12), delelatine (23), and 6-dehydroeldelidine (24), were isolated for the first time from this plant. Six of the new C19-diterpenoid alkaloids (2, 4-7, and 11) and three of the known diterpenoid alkaloids (18, 23, and 24) were evaluated for cytotoxic activity against five human tumor cell lines.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aconitum / Delphinium / Diterpenos / Alcaloides Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aconitum / Delphinium / Diterpenos / Alcaloides Idioma: En Ano de publicação: 2022 Tipo de documento: Article