Are the N-demethylated metabolites of U-47700 more active than their parent compound? In vitro µ-opioid receptor activation of N-desmethyl-U-47700 and N,N-bisdesmethyl-U-47700.

Nordmeier, Frederike; Cannaert, Annelies; Stove, Christophe P; Schmidt, Peter H; Meyer, Markus R; Schaefer, Nadine

Nordmeier, Frederike; Cannaert, Annelies; Stove, Christophe P; Schmidt, Peter H; Meyer, Markus R; Schaefer, Nadine.

Afiliação

Nordmeier F; Institute of Legal Medicine, Saarland University, Homburg, Germany.
Cannaert A; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
Stove CP; Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
Schmidt PH; Institute of Legal Medicine, Saarland University, Homburg, Germany.
Meyer MR; Department of Experimental and Clinical Toxicology, Saarland University, Homburg, Germany.
Schaefer N; Institute of Legal Medicine, Saarland University, Homburg, Germany.

Drug Test Anal ; 14(4): 713-717, 2022 Apr.

Article em En | MEDLINE | ID: mdl-34669261

Assuntos

Benzamidas; Hidromorfona; Analgésicos Opioides/farmacologia; Animais; Luciferases; Suínos

Palavras-chave

NanoLuc Binary Technology®; U-47700; live cell-based reporter assay; new synthetic opioids; µ-opioid receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidas / Hidromorfona Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidas / Hidromorfona Idioma: En Ano de publicação: 2022 Tipo de documento: Article