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Per- and polyfluoroalkyl substances, epigenetic age and DNA methylation: a cross-sectional study of firefighters.
Goodrich, Jaclyn M; Calkins, Miriam M; Caban-Martinez, Alberto J; Stueckle, Todd; Grant, Casey; Calafat, Antonia M; Nematollahi, Amy; Jung, Alesia M; Graber, Judith M; Jenkins, Timothy; Slitt, Angela L; Dewald, Alisa; Cook Botelho, Julianne; Beitel, Shawn; Littau, Sally; Gulotta, John; Wallentine, Darin; Hughes, Jeff; Popp, Charles; Burgess, Jefferey L.
Afiliação
  • Goodrich JM; Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.
  • Calkins MM; National Institute for Occupational Safety & Health, Centers for Disease Control & Prevention, Cincinnati, OH 45226, USA.
  • Caban-Martinez AJ; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
  • Stueckle T; National Institute for Occupational Safety & Health, Centers for Disease Control & Prevention, Morgantown, WV 26505, USA.
  • Grant C; Fire Protection Research Foundation, Quincy, MA 02169, USA.
  • Calafat AM; National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA.
  • Nematollahi A; Department of Community, Environment & Policy, University of Arizona Mel & Enid Zuckerman College of Public Health, Tucson, AZ 85724, USA.
  • Jung AM; Department of Epidemiology & Biostatistics, University of Arizona Mel & Enid Zuckerman College of Public Health, Tucson, AZ 85724, USA.
  • Graber JM; Department of Biostatistics & Epidemiology, Rutgers the State University of New Jersey, Piscataway, NJ 08854, USA.
  • Jenkins T; Department of Cell Biology & Physiology, Brigham Young University, Provo, UT 84602, USA.
  • Slitt AL; Department of Biomedical Sciences, University of Rhode Island College of Pharmacy, Kingston, RI 02881, USA.
  • Dewald A; Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.
  • Cook Botelho J; National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA.
  • Beitel S; Department of Community, Environment & Policy, University of Arizona Mel & Enid Zuckerman College of Public Health, Tucson, AZ 85724, USA.
  • Littau S; Department of Community, Environment & Policy, University of Arizona Mel & Enid Zuckerman College of Public Health, Tucson, AZ 85724, USA.
  • Gulotta J; Tucson Fire Department, Tucson, AZ 85701, USA.
  • Wallentine D; Tucson Fire Department, Tucson, AZ 85701, USA.
  • Hughes J; Orange County Fire Authority, Irvine, CA 92602, USA.
  • Popp C; Boston Fire Department, Boston, MA 02118, USA.
  • Burgess JL; Department of Community, Environment & Policy, University of Arizona Mel & Enid Zuckerman College of Public Health, Tucson, AZ 85724, USA.
Epigenomics ; 13(20): 1619-1636, 2021 10.
Article em En | MEDLINE | ID: mdl-34670402
ABSTRACT

Background:

Per- and polyfluoroalkyl substances (PFASs) are persistent chemicals that firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as PFASs toxicity biomarkers.

Methods:

With a sample size of 197 firefighters, we quantified the serum concentrations of nine PFASs, blood leukocyte DNA methylation and epigenetic age indicators via the EPIC array. We examined the associations between PFASs with epigenetic age, site- and region-specific DNA methylation, adjusting for confounders.

Results:

Perfluorohexane sulfonate, perfluorooctanoate (PFOA) and the sum of branched isomers of perfluorooctane sulfonate (Sm-PFOS) were associated with accelerated epigenetic age. Branched PFOA, linear PFOS, perfluorononanoate, perfluorodecanoate and perfluoroundecanoate were associated with differentially methylated loci and regions.

Conclusion:

PFASs concentrations are associated with accelerated epigenetic age and locus-specific DNA methylation. The implications for PFASs toxicity merit further investigation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Substâncias Perigosas / Exposição Ocupacional / Metilação de DNA / Bombeiros / Epigênese Genética Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Substâncias Perigosas / Exposição Ocupacional / Metilação de DNA / Bombeiros / Epigênese Genética Idioma: En Ano de publicação: 2021 Tipo de documento: Article