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Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells.
Wilson, Paul A; Santos Franco, Sara; He, Liu; Galwey, Nicholas W; Meakin, Jackie; McIntyre, Rebecca; McHugh, Simon M; Nolan, Michael A; Spain, Sarah L; Carlson, Thaddeus; Lobera, Mercedes; Rubio, Justin P; Davis, Bill; McCarthy, Linda C.
Afiliação
  • Wilson PA; Human Genetics, GlaxoSmithKline Medicine Research Centre, Stevenage, England.
  • Santos Franco S; Clinical Unit Cambridge, Addenbrooke's Centre for Clinical Investigation, GlaxoSmithKline, Cambridge, England.
  • He L; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
  • Galwey NW; Research Statistics, GlaxoSmithKline Medicines Research Centre, Stevenage, England.
  • Meakin J; Functional Genomics, GlaxoSmithKline Medicines Research Centre, Stevenage, England.
  • McIntyre R; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
  • McHugh SM; Clinical Unit Cambridge, Addenbrooke's Centre for Clinical Investigation, GlaxoSmithKline, Cambridge, England.
  • Nolan MA; Quench Bio, Cambridge, MA, England.
  • Spain SL; Open Targets, Hinxton, Cambridge, England.
  • Carlson T; Adaptive Immunity, GSK Pharma Research & Development, Cambridge, MA, United States of America.
  • Lobera M; Adaptive Immunity, GSK Pharma Research & Development, Cambridge, MA, United States of America.
  • Rubio JP; Department of Pharmacology and Therapeutics, The University of Melbourne, Victoria, Australia.
  • Davis B; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
  • McCarthy LC; Clinical Unit Cambridge, Addenbrooke's Centre for Clinical Investigation, GlaxoSmithKline, Cambridge, England.
PLoS One ; 16(10): e0258316, 2021.
Article em En | MEDLINE | ID: mdl-34673799
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Doenças Inflamatórias Intestinais / Linfócitos T CD4-Positivos / Polimorfismo de Nucleotídeo Único / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Transcriptoma / Hipersensibilidade Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Doenças Inflamatórias Intestinais / Linfócitos T CD4-Positivos / Polimorfismo de Nucleotídeo Único / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Transcriptoma / Hipersensibilidade Idioma: En Ano de publicação: 2021 Tipo de documento: Article