[Advances in basic and translational research in neuroendocrine neoplasms].
Zhonghua Wei Chang Wai Ke Za Zhi
; 24(10): 867-874, 2021 Oct 25.
Article
em Zh
| MEDLINE
| ID: mdl-34674461
ABSTRACT
With the development of diagnostic techniques and the improvement of people's living standards, the detection rate of neuroendocrine tumor has been increasing and people are paying more and more attention to it. With multiple treatment modalities, the clinical research progress of neuroendocrine tumor is remarkable. However, due to the tumor heterogeneity, metastasis and recurrence of neuroendocrine tumor remains a difficult problem for clinicians. The efficacy of neuroendocrine tumor still needs to be improved. Therefore, the biological behavior of neuroendocrine tumor needs to be further studied. In recent years, with the development of molecular biology, the basic and transformation research of neuroendocrine tumor has made some progress. In this paper, we focus on the hot topics of neuroendocrine tumor, such as multiomics (copy number variation, genomics, transcriptomics), tumor microenvironment (immune microenvironment, tumor microvasculature, tumor-associated fibroblasts, etc.), preclinical research model construction (cell lines, organoids, patient derived xenograft models, genetically engineered mice), etc. Specifically, the related clinical transformation significance will be elaborated.
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MEDLINE
Assunto principal:
Tumores Neuroendócrinos
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Pesquisa Translacional Biomédica
Idioma:
Zh
Ano de publicação:
2021
Tipo de documento:
Article