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Feasibility of age- and gestation-based routine universal influenza vaccines schedules for children aged 6 months - 2 years and pregnant women.
Dang, T K N Sandra; Rivero Cabrera, Romén; Yeung, Karene Hoi Ting; van der Putten, Ingeborg M; Nelson, E Anthony S.
Afiliação
  • Dang TKNS; CAPHRI, Care and Public Health Research Institute, Department of Health Services Research, Maastricht University, Maastricht, the Netherlands. Electronic address: dang.sandra.kn@gmail.com.
  • Rivero Cabrera R; CAPHRI, Care and Public Health Research Institute, Department of Health Services Research, Maastricht University, Maastricht, the Netherlands. Electronic address: romenrivero@gmail.com.
  • Yeung KHT; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong. Electronic address: karene@link.cuhk.edu.hk.
  • van der Putten IM; CAPHRI, Care and Public Health Research Institute, Department of Health Services Research, Maastricht University, Maastricht, the Netherlands. Electronic address: i.vanderputten@maastrichtuniversity.nl.
  • Nelson EAS; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong. Electronic address: tony-nelson@cuhk.edu.hk.
Vaccine ; 39(46): 6754-6761, 2021 11 05.
Article em En | MEDLINE | ID: mdl-34674893
BACKGROUND: Hong Kong's seasonal influenza schedule follows the World Health Organization's northern hemisphere vaccine composition recommendations but with year-round influenza activity there is the potential to implement routine age- and gestation-based schedules utilising both northern and southern hemisphere vaccines for children aged 6 months to 2 years and for pregnant women. This study assessed the potential feasibility of such schedules. METHODS: A literature review was conducted and in-depth interviews with vaccine experts, policy makers and nurses were undertaken. RESULTS: The following schedules were proposed and assessed for perceived feasibility: 1) a four-dose schedule in the first two years of life requiring an additional unscheduled clinic visit at 7 months; 2) a three-dose schedule excluding the 4-week booster after the first dose; 3) a two-dose schedule for pregnant women involving a dose at the booking visit and a dose with pertussis vaccine at 7 months gestation; and 4) a one-dose schedule at 7 months gestation. CONCLUSIONS: Age- and gestation-based routine influenza vaccination schedules are theoretically feasible for both young children and pregnant women. The three-dose paediatric and one-dose obstetric schedules were assessed in interviews with vaccine experts, policy makers and nurses to be most acceptable. Further clinical studies are required to determine whether such schedules are non-inferior to current seasonal-based schedules in terms of vaccine effectiveness and vaccine uptake.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Influenza Humana Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Influenza Humana Idioma: En Ano de publicação: 2021 Tipo de documento: Article