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Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis.
Bhattacharya, Dipankar; Becker, Christine; Readhead, Benjamin; Goossens, Nicolas; Novik, Jacqueline; Fiel, Maria Isabel; Cousens, Leslie P; Magnusson, Björn; Backmark, Anna; Hicks, Ryan; Dudley, Joel T; Friedman, Scott L.
Afiliação
  • Bhattacharya D; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, Box 1123, 1425 Madison Ave. Room 1170, New York, NY, 10029, USA.
  • Becker C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Readhead B; Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Goossens N; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Novik J; Arizona State University-Banner Neurodegenerative Disease Research Center, Arizona, USA.
  • Fiel MI; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, Box 1123, 1425 Madison Ave. Room 1170, New York, NY, 10029, USA.
  • Cousens LP; Division of Gastroenterology, Geneva University Hospital, Geneva, Switzerland.
  • Magnusson B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Backmark A; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Hicks R; Emerging Innovations, Discovery Sciences, R&D, AstraZeneca, Boston, MA, USA.
  • Dudley JT; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Friedman SL; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
Sci Rep ; 11(1): 20827, 2021 10 21.
Article em En | MEDLINE | ID: mdl-34675338
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Fosfínicos / Propilaminas / Agonistas dos Receptores de GABA-B / Reposicionamento de Medicamentos / Hepatopatia Gordurosa não Alcoólica / Fígado Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Fosfínicos / Propilaminas / Agonistas dos Receptores de GABA-B / Reposicionamento de Medicamentos / Hepatopatia Gordurosa não Alcoólica / Fígado Idioma: En Ano de publicação: 2021 Tipo de documento: Article