Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells.
Genes (Basel)
; 12(10)2021 09 24.
Article
em En
| MEDLINE
| ID: mdl-34680880
ABSTRACT
Populations of resident stem cells (SCs) are responsible for maintaining, repairing, and regenerating adult tissues. In addition to having the capacity to generate all the differentiated cell types of the tissue, adult SCs undergo long periods of quiescence within the niche to maintain themselves. The process of SC renewal and differentiation is tightly regulated for proper tissue regeneration throughout an organisms' lifetime. Epigenetic regulators, such as the polycomb group (PcG) of proteins have been implicated in modulating gene expression in adult SCs to maintain homeostatic and regenerative balances in adult tissues. In this review, we summarize the recent findings that elucidate the composition and function of the polycomb repressive complex machinery and highlight their role in diverse adult stem cell compartments.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Epigênese Genética
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Proteínas do Grupo Polycomb
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Complexo Repressor Polycomb 1
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Complexo Repressor Polycomb 2
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article