Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues.
J Vet Med Sci
; 83(12): 1885-1890, 2021 Dec 02.
Article
em En
| MEDLINE
| ID: mdl-34690223
ABSTRACT
Cancer immunotherapy is a novel cancer treatment for canine tumors. Indoleamine 2,3-dioxygenase 1 (IDO1) is overexpressed in some human tumors and inhibits antitumor immunity. In this study, we comprehensively evaluated expression pattern of IDO1 and the nature of IDO1-expressing cells in canine normal and tumor tissues. In normal tissue samples, IDO1 expression was detected only in the lymph nodes, spleen, tonsil tissues, and colon tissues. In contrast, IDO1-positive tumor cells were observed in several tumor tissue types. This is the first study to evaluate IDO1 expression in canine normal and tumor tissues, and the results suggest that IDO1 is a promising target for novel cancer immunotherapy in dogs with tumors.
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MEDLINE
Assunto principal:
Doenças do Cão
/
Neoplasias
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article