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Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo.
Schueffl, Hemma; Theiner, Sarah; Hermann, Gerrit; Mayr, Josef; Fronik, Philipp; Groza, Diana; van Schonhooven, Sushilla; Galvez, Luis; Sommerfeld, Nadine S; Schintlmeister, Arno; Reipert, Siegfried; Wagner, Michael; Mader, Robert M; Koellensperger, Gunda; Keppler, Bernhard K; Berger, Walter; Kowol, Christian R; Legin, Anton; Heffeter, Petra.
Afiliação
  • Schueffl H; Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna Borschkegasse 8a A-1090 Vienna Austria petra.heffeter@meduniwien.ac.at +43-1-40160-957555 +43-1-40160-57594.
  • Theiner S; Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna Waehringer Str. 38 A-1090 Vienna Austria.
  • Hermann G; Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna Waehringer Str. 38 A-1090 Vienna Austria.
  • Mayr J; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna Waehringer Str. 42 A-1090 Vienna Austria anton.legin@univie.ac.at christian.kowol@univie.ac.at +43-1-4277-852601 +43-1-4277-9526 +43-1-4277-52610 +43-1-4277-52611.
  • Fronik P; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna Waehringer Str. 42 A-1090 Vienna Austria anton.legin@univie.ac.at christian.kowol@univie.ac.at +43-1-4277-852601 +43-1-4277-9526 +43-1-4277-52610 +43-1-4277-52611.
  • Groza D; Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna Borschkegasse 8a A-1090 Vienna Austria petra.heffeter@meduniwien.ac.at +43-1-40160-957555 +43-1-40160-57594.
  • van Schonhooven S; Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna Borschkegasse 8a A-1090 Vienna Austria petra.heffeter@meduniwien.ac.at +43-1-40160-957555 +43-1-40160-57594.
  • Galvez L; Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna Waehringer Str. 38 A-1090 Vienna Austria.
  • Sommerfeld NS; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna Waehringer Str. 42 A-1090 Vienna Austria anton.legin@univie.ac.at christian.kowol@univie.ac.at +43-1-4277-852601 +43-1-4277-9526 +43-1-4277-52610 +43-1-4277-52611.
  • Schintlmeister A; Centre for Microbiology and Environmental Systems Science, Division of Microbial Ecology and Large-Instrument Facility for Environmental and Isotope Mass Spectrometry, University of Vienna Djerassiplatz 1 A-1030 Vienna Austria.
  • Reipert S; Core Facility Cell Imaging and Ultrastructure Research, University of Vienna, University Biology Building (UBB) Djerassiplatz 1 A-1030 Vienna Austria.
  • Wagner M; Centre for Microbiology and Environmental Systems Science, Division of Microbial Ecology and Large-Instrument Facility for Environmental and Isotope Mass Spectrometry, University of Vienna Djerassiplatz 1 A-1030 Vienna Austria.
  • Mader RM; Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna Waehringer Guertel 18-20 1090 Vienna Austria.
  • Koellensperger G; Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna Waehringer Str. 38 A-1090 Vienna Austria.
  • Keppler BK; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna Waehringer Str. 42 A-1090 Vienna Austria anton.legin@univie.ac.at christian.kowol@univie.ac.at +43-1-4277-852601 +43-1-4277-9526 +43-1-4277-52610 +43-1-4277-52611.
  • Berger W; Research Cluster "Translational Cancer Therapy Research", University of Vienna, Medical University of Vienna Vienna Austria.
  • Kowol CR; Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna Borschkegasse 8a A-1090 Vienna Austria petra.heffeter@meduniwien.ac.at +43-1-40160-957555 +43-1-40160-57594.
  • Legin A; Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna Waehringer Guertel 18-20 1090 Vienna Austria.
  • Heffeter P; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna Waehringer Str. 42 A-1090 Vienna Austria anton.legin@univie.ac.at christian.kowol@univie.ac.at +43-1-4277-852601 +43-1-4277-9526 +43-1-4277-52610 +43-1-4277-52611.
Chem Sci ; 12(38): 12587-12599, 2021 Oct 06.
Article em En | MEDLINE | ID: mdl-34703544
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article