Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson's Disease.
Bull Exp Biol Med
; 171(6): 716-721, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34705173
ABSTRACT
A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and blood serum of animals, which can be associated with decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes apparently make an important contribution into neuronal degeneration in the cerebral cortex and striatum and motor disorders in experimental animals.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson Secundária
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Superóxido Dismutase
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Catalase
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Glutationa
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Glutationa Peroxidase
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Glutationa Redutase
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Glutationa Transferase
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article