Reduced Thickness of the Anterior Cingulate Cortex as a Predictor of Amnestic-Mild Cognitive Impairment Conversion to Alzheimer's Disease with Psychosis.
J Alzheimers Dis
; 84(4): 1709-1717, 2021.
Article
em En
| MEDLINE
| ID: mdl-34719496
ABSTRACT
BACKGROUND:
A long-term follow-up study in patients with amnestic mild cognitive impairment (aMCI) is needed to elucidate the association between regional brain volume and psychopathological mechanisms of Alzheimer's disease with psychosis (ADâ+âP).OBJECTIVE:
The purpose of this study was to investigate the effect of the thickness of the angular cingulate cortex (ACC) on the risk of ADâ+âP conversion in patients with aMCI.METHODS:
This was a hospital-based prospective longitudinal study including 174 patients with aMCI. The main outcome measure was time-to-progression from aMCI to ADâ+âP. Subregions of the ACC (rostral ACC, rACC; caudal ACC, cACC) and hippocampus (HC) were measured as regions of interest with magnetic resonance imaging and the Freesurfer analysis at baseline. Survival analysis with time to incident ADâ+âP as an event variable was calculated with Cox proportional hazards models using the subregions of the ACC and HC as a continuous variable.RESULTS:
Cox proportional hazard analyses showed that the risk of ADâ+âP was associated with sub-regional ACC thickness but not HC volume reduced cortical thickness of the left cACC (HR [95%CI], 0.224 [0.087-0.575], pâ=â0.002), right cACC (HR [95%CI], 0.318 [0.132-0.768], pâ=â0.011). This association of the cACC with the risk of AD also remained significant when adjusted for HC volume.CONCLUSION:
We found that reduced cortical thickness of the cACC is a predictor of aMCI conversion to ADâ+âP, independent of HC, suggesting that the ACC plays a vital role in the underlying pathogenesis of ADâ+âP.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
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Progressão da Doença
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Doença de Alzheimer
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Disfunção Cognitiva
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Giro do Cíngulo
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Amnésia
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Testes Neuropsicológicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article