Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice.

Miura, Tomonori; Uehara, Shotaro; Shimizu, Makiko; Murayama, Norie; Suemizu, Hiroshi; Yamazaki, Hiroshi

Miura, Tomonori; Uehara, Shotaro; Shimizu, Makiko; Murayama, Norie; Suemizu, Hiroshi; Yamazaki, Hiroshi.

Afiliação

Miura T; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University.
Uehara S; Laboratory Animal Research Department, Central Institute for Experimental Animals.
Shimizu M; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University.
Murayama N; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University.
Suemizu H; Laboratory Animal Research Department, Central Institute for Experimental Animals.
Yamazaki H; Laboratory Animal Research Department, Central Institute for Experimental Animals.

J Toxicol Sci ; 46(11): 525-530, 2021.

Article em En | MEDLINE | ID: mdl-34719555

Assuntos

Cumarínicos; Citocromo P-450 CYP1A2; Animais; Cumarínicos/toxicidade; Hepatócitos; Humanos; Camundongos; Microssomos Hepáticos; Teofilina/análogos & derivados

Palavras-chave

7-Hydroxycoumarin; Humanized-liver mouse; Mechanism-based inhibitor; âo-Hydroxyphenylacetic acid

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP1A2 / Cumarínicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP1A2 / Cumarínicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article